|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_057306, 21071032|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 68 kDa |
Observed: 70 kDa
|Application Notes||DDX41 antibody can be used for detection of DDX41 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||DDX41; At least two isoforms of DDX41 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||DDX41 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||DDX41 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.|
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Provided below are standard protocols that you may find useful for product applications.
DDX41 Antibody: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX41, also known as Abstrakt, interacts with and regulates the expression of sorting nexin-2 (SNX2), a protein involved in protein sorting in the trans-Golgi network. Recent evidence suggests that DDX41 also plays a role in the innate immune response by sensing intracellular viral DNA, triggering TBK1 and IRF3 activation, leading to a type I interferon immune response.
Cordin O, Banroques J, Tanner NK, et al. The DEAD-box protein family of RNA helicases. Gene 2006; 367:17-37.
Linder P. Dead-box proteins: a family affair—active and passive players in RNP-remodeling. Nucleic Acids Res. 2006; 34:4168-80.
Abdul-Ghani M, Hartman KL, and Ngsee JK. Abstrakt interacts with and regulates the expression of sorting nexin-2. J. Cell Physiol. 2005; 204:210-8.
Zhang Z, Yuan B, Bao M, et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 2011; 12:959-65.
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