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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   TLX1 Antibody   

TLX1 Antibody

  • WB - TLX1 Antibody ASC11661
    Western blot analysis of TLX1 in mouse spleen tissue lysate with TLX1 antibody at (A) 1 µg/mL and (B) 2 µg/mL.
  • IHC - TLX1 Antibody ASC11661
    Immunohistochemistry of TLX1 in human spleen tissue with TLX1 antibody at 2.5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31314
Other Accession NP_005512, 5031757
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 36 kDa

Observed: 35 kDa
Application Notes TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 3195
Target/Specificity TLX1; Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.
Reconstitution & Storage TLX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTLX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLX1
Synonyms HOX11, TCL3
Function Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Cellular Location Nucleus.
Research Areas
Citations (0)

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TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.


Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14). Blood 1991; 78:2996-3003.
Hatano M, Roberts CW, Minden M, et al. Deregulation of a homeobox gene, Hox11, by the t (10;14) in T cell leukemia. Science 1991; 253:79-82.
Roberts CW, Shutter JR, Korsmeyer SJ et al. Hox11 controls the genesis of the spleen. Nature 1994; 368:747-9.

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$ 310.00
Cat# ASC11661
(40 western blots)
Availability: 5-7days
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