|Application ||WB, IHC-P, E|
|Other Accession||NP_005512, 5031757|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 36 kDa |
Observed: 35 kDa
|Application Notes||TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||TLX1; Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.|
|Reconstitution & Storage||TLX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TLX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.|
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Provided below are standard protocols that you may find useful for product applications.
TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14). Blood 1991; 78:2996-3003.
Hatano M, Roberts CW, Minden M, et al. Deregulation of a homeobox gene, Hox11, by the t (10;14) in T cell leukemia. Science 1991; 253:79-82.
Roberts CW, Shutter JR, Korsmeyer SJ et al. Hox11 controls the genesis of the spleen. Nature 1994; 368:747-9.
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