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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Bim EL Antibody   

Bim EL Antibody

  • WB - Bim EL Antibody ASC11677
    Western blot analysis of Bim in K562 cell lysate with Bim EL antibody at (A) 1 and (B) 2 µg/mL.
  • ICC - Bim EL Antibody ASC11677
    Immunocytochemistry of BIM EL inK562 cells with BIM EL antibody at 2.5 µg/ml.
  • IF - Bim EL Antibody ASC11677
    Immunofluorescence of BIM EL in K562 cells with BIM EL antibody at 2.5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43521
Other Accession NP_619527, 20336315
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 22 kDa

Observed: 24 kDa
Application Notes Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 10018
Target/Specificity BCL2L11; Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist; this antibody only detects the Bim EL isoform.
Reconstitution & Storage Bim EL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsBim EL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L11
Synonyms BIM
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Cellular Location Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimL: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.
Tissue Location Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney
Research Areas
Citations (0)

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Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).


O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.
Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.

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$ 310.00
Cat# ASC11677
(40 western blots)
Availability: 5-7days
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