|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_861445, 145580621|
|Calculated MW||Predicted: 32 kDa |
|Application Notes||BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||BTLA; BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.|
|Reconstitution & Storage||BTLA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||BTLA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).
Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.
Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.
Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.
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