|Application ||WB, IF, E|
|Other Accession||NP_037483, 7019549|
|Calculated MW||Predicted: 59 kDa |
|Application Notes||TBX21 antibody can be used for detection of TBX21 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||TBX21; TBX21 antibody is human and mouse reactive.|
|Reconstitution & Storage||TBX21 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TBX21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.|
|Tissue Location||T-cell specific.|
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Provided below are standard protocols that you may find useful for product applications.
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2). Members of this family include transcription factors involved in the regulation of developmental processes (2). Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3). Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3).
Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.
Naiche LA, Harrelson Z, Kelly RG, et al. T-box genes in vertebrate development. Annu. Rev. Genet. 2005; 39:219-39.
Hibbert L, Pflanz S, De Waal Malefyt R, et al. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interfeon Cytokine Res. 2003; 23:513-22.
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