|Application ||WB, IF, E|
|Other Accession||NP_055475, 55769548|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 98 kDa |
|Application Notes||PHF14 antibody can be used for detection of PHF14 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||PHF14; PHF14 antibody is human, mouse and rat reactive. Multiple isoforms of PHF14 are known to exist.|
|Reconstitution & Storage||PHF14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||PHF14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
PHF14, a novel plant homology domain (PHD) transcription factor, controls the proliferation of mesenchymal cells by regulating PDGFR alpha expression in embryonic development (1). PHD finger transcription factors are concerned with transcriptional regulation by interacting with modified histones (2), and dysregulation of several genes encoding PHD finger transcription factors, such as ING1 and RBP2, has been found in human cancer diseases suggesting these factors have an important role for cancer cell proliferation. PHF14 is a potential target for new treatments of lung fibrosis (1, 3).
Kitagawa M, Takebe A, Ono Y, et al. Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-a. J. Biol. Chem. 2012; 287:27983-96.
Musco G and Peterson P. PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics 2008; 3:310-4.
Musselman CA and Kutateladze TG. PHD fingers: epigenetic effectors and potential drug targets. Mol. Interv. 2009; 9:314-23.
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