|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_000581, 10834980|
|Calculated MW||Predicted: 13 kDa |
|Application Notes||IL-9 antibody can be used for detection of IL-9 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||IL9; IL-9 antibody is human specific. IL-9 antibody is predicted to no cross-react with IL-7.|
|Reconstitution & Storage||IL-9 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IL-9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Supports IL-2 independent and IL-4 independent growth of helper T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2). It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3). The IL-9 gene has been identified as a candidate gene for asthma (4). Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5).
Renauld JC, Goethals A, Houssiau F, et al. Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine 1990; 2:9-12.
Tete S, Saggini A, Maccauro G, et al. Interleukin-9 and mast cells. J. Biol. Homeost. Agents 2012; 26:319-26.
Knoops L and Renauld JC. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 2004; 22:207-15.
Nicolaides NC, Holroyd KJ, Ewart SL, et al. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA 1997; 94:13175-80.
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