|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_444269, 151101369|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 22 kDa |
Observed: 21 kDa
|Application Notes||COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||COMMD7; COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.|
|Reconstitution & Storage||COMMD7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||COMMD7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).|
|Cellular Location||Cytoplasmic vesicle|
|Tissue Location||Widely expressed with highest expression in lung.|
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Provided below are standard protocols that you may find useful for product applications.
COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).
Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.
Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.
Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry 2007; 46:3116-28.
Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.
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