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PPFIA3 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75145 |
| Other Accession | NP_003651, 32189362 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 131 kDa Observed: 131 kDa |
| Application Notes | PPFIA3 antibody can be used for detection of PPFIA3 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 8541 |
|---|---|
| Target/Specificity | PPFIA3; PPFIA3 antibody is human, mouse, and rat reactive. |
| Reconstitution & Storage | PPFIA3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | PPFIA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPFIA3 |
|---|---|
| Synonyms | KIAA0654 |
| Function | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91Z79}. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Also detected in epididymosome {ECO:0000250|UniProtKB:Q91Z79} |
| Tissue Location | Predominantly expressed in brain (PubMed:9624153). Also detected in sperm (at protein level) (PubMed:23124857) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The PPFIA3 protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family, a family of transmembrane protein tyrosine phosphatases known to be important for axon guidance and mammary gland development (1). Similar to the other liprin family members, PPFIA3 can interact with ERC2, a member of the ELKS-Rab6-interacting protein-CAST family of proteins at the presynaptic termini, suggesting that these proteins may play a role in the molecular organization of presynaptic zones (2).
References
Serra-Pages C, Medley QG, Tang M, et al. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 1998; 273:15611-20.
Ko J, Na M, Kim S, et al. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. J. Biol. Chem. 2003; 278:42377-85.
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