|Application ||WB, E|
|Other Accession||NP_003651, 32189362|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 131 kDa |
Observed: 131 kDa
|Application Notes||PPFIA3 antibody can be used for detection of PPFIA3 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||PPFIA3; PPFIA3 antibody is human, mouse, and rat reactive.|
|Reconstitution & Storage||PPFIA3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||PPFIA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.|
|Cellular Location||Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface|
|Tissue Location||Expressed only in brain.|
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Provided below are standard protocols that you may find useful for product applications.
The PPFIA3 protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family, a family of transmembrane protein tyrosine phosphatases known to be important for axon guidance and mammary gland development (1). Similar to the other liprin family members, PPFIA3 can interact with ERC2, a member of the ELKS-Rab6-interacting protein-CAST family of proteins at the presynaptic termini, suggesting that these proteins may play a role in the molecular organization of presynaptic zones (2).
Serra-Pages C, Medley QG, Tang M, et al. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 1998; 273:15611-20.
Ko J, Na M, Kim S, et al. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. J. Biol. Chem. 2003; 278:42377-85.
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