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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPFIA3 Antibody   

PPFIA3 Antibody

     
  • WB - PPFIA3 Antibody ASC11723
    Western blot analysis of PPFIA3 in 293 cell lysate with PPFIA3 antibody at (A) 1 and (B) 2 µg/ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75145
Other Accession NP_003651, 32189362
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 131 kDa

Observed: 131 kDa
Application Notes PPFIA3 antibody can be used for detection of PPFIA3 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 8541
Target/Specificity PPFIA3; PPFIA3 antibody is human, mouse, and rat reactive.
Reconstitution & Storage PPFIA3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPPFIA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPFIA3
Synonyms KIAA0654
Function May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q91Z79}. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Also detected in epididymosome. {ECO:0000250|UniProtKB:Q91Z79}
Tissue Location Predominantly expressed in brain (PubMed:9624153). Also detected in sperm (at protein level) (PubMed:23124857).
Research Areas
Citations (0)

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Background

The PPFIA3 protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family, a family of transmembrane protein tyrosine phosphatases known to be important for axon guidance and mammary gland development (1). Similar to the other liprin family members, PPFIA3 can interact with ERC2, a member of the ELKS-Rab6-interacting protein-CAST family of proteins at the presynaptic termini, suggesting that these proteins may play a role in the molecular organization of presynaptic zones (2).

References

Serra-Pages C, Medley QG, Tang M, et al. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 1998; 273:15611-20.
Ko J, Na M, Kim S, et al. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. J. Biol. Chem. 2003; 278:42377-85.

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$ 320.00
Cat# ASC11723
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