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APPBP2 Antibody

  • WB - APPBP2 Antibody ASC11724
    Western blot analysis of APPBP2 in human brain tissue lysate with APPBP2 antibody at (A) 0.5 and (B) 1 µg/ml.
  • IHC - APPBP2 Antibody ASC11724
    Immunohistochemistry of APPBP2 in human brain tissue with APPBP2 antibody at 5 µg/mL.
  • IF - APPBP2 Antibody ASC11724
    Immunofluorescence of APPBP2 in human brain tissue with APPBP2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92624
Other Accession NP_006371, 18104962
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 64 kDa

Observed: 57 kDa
Application Notes APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 10513
Target/Specificity APPBP2; APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage APPBP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsAPPBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0228, PAT1
Function May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
Cellular Location Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein Note=Associated with membranes and microtubules
Research Areas
Citations (0)

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The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).


Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.
Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.

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$ 310.00
Cat# ASC11724
(40 western blots)
Availability: 5-7days
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