|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_006371, 18104962|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 64 kDa |
Observed: 57 kDa
|Application Notes||APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||APPBP2; APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||APPBP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||APPBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein Note=Associated with membranes and microtubules|
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Provided below are standard protocols that you may find useful for product applications.
The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).
Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.
Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.
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