|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_996663, 45592949|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 29 kDa |
Observed: 24 kDa
|Application Notes||TMIGD1 antibody can be used for detection of TMIGD1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||TMIGD1; TMIGD1 antibody is human, mouse and rat reactive. At least two isoforms of TMIGD1 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||TMIGD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TMIGD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cytoplasm|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TMIGD1 (transmembrane and immunoglobulin domain containing 1) is a 262 amino acid single-pass membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains (1,2). It is a nonsecreted, glycosylated protein located in the cytoplasm and cell membrane (1). TMIGD1 might be a possible cell-differentiation marker in the intestine, whose expression is lost during cellular transformation and promote progression of tumorigenesis in the intestinal epithelium (2-4). TMIGD1 has also been postulated to play a role in cell adhesion (2).
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.
Fujimoto K, Beauchamp RD, Whitehead RH. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology 2002; 123:1941–8.
Yan J, Jiang J, Lim CA, et al. Blimp-1 regulates cell growth through repression of p53 transcription. Proc. Natl. Acad. Sci. USA 2007; 104:1841-6.
Cattaneo E, Laczko E, Buffoli F, et al. Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid). EMBO Mol Med. 2011; 3:334-47.
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