|Application ||WB, E|
|Other Accession||NP_001135920, 215490098|
|Calculated MW||Predicted: 58 kDa |
Observed: 70 kDa
|Application Notes||SPINSTER antibody can be used for detection of SPINSTER by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||SPNS1; SPINSTER antibody is human specific. At least four isoforms of SPINSTER are known to exist. This antibody is predicted to not cross-react with other members of the spinster family of proteins.|
|Reconstitution & Storage||SPINSTER antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||SPINSTER Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein. Note=Colocalizes with SDHB|
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Provided below are standard protocols that you may find useful for product applications.
SPINSTER, also known as SPNS1 or SPIN1, is a 528 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and belongs to the spinster subfamily of the major facilitator superfamily (1). SPINSTER interacts with Bcl-x and Bcl-2 and, via this interaction, is thought to be involved in necrotic or autophagic cell death (2). The related protein SPNS2 is critical for the normal lymphocyte localization and mammalian immune system function (1,3).
Saier MH Jr, Beatty JT, Goffeau A, et al. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1999; 1:257-79.
Yanagisawa H, Miyashita T, Nakano Y, et al. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ. 2003; 10:798-807.
Nakano Y, Fujitani K, Kurihara J, et al. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 2001; 21:3775-88.
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