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CASR Antibody

  • WB - CASR Antibody ASC11796
    Western blot analysis of CASR in EL4 cell lysate with CASR antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - CASR Antibody ASC11796
    Immunohistochemistry of CASR in human kidney tissue with CASR antibody at 5 µg/mL.
  • IF - CASR Antibody ASC11796
    Immunofluorescence of CASR in human kidney tissue with CASR antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41180
Other Accession NP_001171536, 296010811
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 101, 120 kDa

Observed: 115, 125 kDa
Application Notes CASR antibody can be used for detection of CASR by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Additional Information
Gene ID 846
Target/Specificity CASR; CASR antibody is human, mouse and rat reactive. At least two isoforms of CASR are known to exist.
Reconstitution & Storage CASR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsCASR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPRC2A, PCAR1
Function Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta
Research Areas
Citations (0)

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The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1,2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).


Pollak MR, Brown EM, Chou YH, et al. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 1993; 75:1297-303.
Jakobsen SF, Rolighed L, Nissen PH, et al. Muscle function and quality of life are not impaired in familial hypocalciuric hypercalcemia: a cross-sectional study on physiological effects of inactivating variants in the calcium-sensing receptor gene (CASR). Eur. J. Endocrinol. 2013; 169:349-57.
Li T, Sun M, Yin X, et al. Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-kB pathways. Mol. Immunol. 2013; 53:414-20.

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$ 310.00
Cat# ASC11796
(40 western blots)
Availability: 5-7days
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