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TICRR Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q7Z2Z1 |
| Other Accession | NP_689472, 118421085 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 210 kDa Observed: 220 kDa |
| Application Notes | TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL. |
| Gene ID | 90381 |
|---|---|
| Target/Specificity | TICRR; TICRR antibody is human specific. At least two isoforms of TICRR are known to exist. |
| Reconstitution & Storage | TICRR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | TICRR Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TICRR |
|---|---|
| Synonyms | C15orf42 |
| Function | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. |
| Cellular Location | Nucleus. Note=Associates with chromatin |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42
References
Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.
Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.
Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.
Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.
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