|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_689472, 118421085|
|Calculated MW||Predicted: 210 kDa |
Observed: 220 kDa
|Application Notes||TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.|
|Target/Specificity||TICRR; TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.|
|Reconstitution & Storage||TICRR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TICRR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.|
|Cellular Location||Nucleus. Note=Associates with chromatin|
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Provided below are standard protocols that you may find useful for product applications.
TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42
Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.
Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.
Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.
Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.
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