|Application ||WB, E|
|Other Accession||NP_689614, 51944950|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 27 kDa |
Observed: 25 kDa
|Application Notes||PDCL2 antibody can be used for detection of PDCL2 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||PDCL2; PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.|
|Reconstitution & Storage||PDCL2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||PDCL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in germ cell maturation.|
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Provided below are standard protocols that you may find useful for product applications.
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL2 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3). PDCL2 has been shown to interact with the chaperonin CCT and is essential for cytoskeletal protein function and cell cycle progression (4).
Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.
Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.
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