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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDCL3 Antibody   

PDCL3 Antibody

  • WB - PDCL3 Antibody ASC11821
    Western blot analysis of PDCL3 in human brain tissue lysate with PDCL3 antibody at 1 µg/ml.
  • IHC - PDCL3 Antibody ASC11821
    Immunohistochemistry of PDCL3 in mouse lver tissue with PDCL3 antibody at 5 µg/mL.
  • IF - PDCL3 Antibody ASC11821
    Immunofluorescence of PDCL3 in mouse liver tissue with PDCL3 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2J4
Other Accession NP_076970, 13129044
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 26 kDa

Observed: 25 kDa
Application Notes PDCL3 antibody can be used for detection of PDCL by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Additional Information
Gene ID 79031
Target/Specificity PDCL3; PDCL3 antibody is human, mouse and rat reactive. PDCL3 antibody is predicted to not cross-react with other members of the PDCL protein family.
Reconstitution & Storage PDCL3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPDCL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCL3
Synonyms PhLP2A, VIAF1
Function Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.
Cellular Location Cytoplasm.
Tissue Location Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
Research Areas
Citations (0)

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Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3). Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding (4). Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling (5).


Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.
Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.

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$ 330.00
Cat# ASC11821
Availability: 5-7days
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