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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SNCA Antibody   

SNCA Antibody

  • WB - SNCA Antibody ASC11829
    Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 µg/ml.
  • IHC - SNCA Antibody ASC11829
    Immunohistochemistry of SNCA in rat brain tissue with SNCA antibody at 5 µg/ml.
  • IF - SNCA Antibody ASC11829
    Immunofluorescence of SNCA in rat brain tissue with SNCA antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P37840
Other Accession NP_000336, 6806898
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 12 kDa

Observed: 16 kDa
Application Notes SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 6622
Target/Specificity SNCA; SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.
Reconstitution & Storage SNCA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSNCA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NACP, PARK1
Function May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Cellular Location Cytoplasm, cytosol Membrane. Nucleus. Cell junction, synapse. Secreted. Note=Membrane-bound in dopaminergic neurons.
Tissue Location Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals
Research Areas
Citations (0)

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Alpha-Synuclein (SNCA) is a hallmark of Alzheimer’s disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson’s disease (4,5).


Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.
Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.
Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.
Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.

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$ 310.00
Cat# ASC11829
(40 western blots)
Availability: 5-7days
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