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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   LIN54 Antibody   

LIN54 Antibody

     
  • IHC - LIN54 Antibody ASC11838
    Immunohistochemistry of MSI2 in mouse brain tissue with MSI2 Antibodyat 5 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, ICC, E
Primary Accession Q6MZP7
Other Accession NP_919258, 132660
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 88 kDa

Observed: 82 kDa
Application Notes LIN54 antibody can be used for detection of LIN54 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL
Additional Information
Gene ID 132660
Target/Specificity LIN54 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human LIN54.

The immunogen is located within the last 50 amino acids of LIN54.
Reconstitution & Storage LIN54 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsLIN54 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIN54
Synonyms CXCDC1, KIAA2037
Function Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes. This complex functions as a transcriptional repressor by binding to promoters of E2F target genes that regulate the G1/S transition (1). LIN54 is required for cell cycle progression and can bind to the cdc2 promoter in a sequence-specific manner (2).

References

Schmit F, Cremer S, and Gaubatz S. LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promotoer in a sequence-specific manner. FEBS J. 2009; 276:5703-16.
Matsuo T, Kuramoto H, Kumazaki T, et al. LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression. Cell Cycle 2012; 11:3227-36.

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$ 320.00
Cat# ASC11838
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