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SKI2W Antibody

  • WB - SKI2W Antibody ASC11860
    Western blot analysis of SKI2W in mouse stomach tissue lysate with SKI2W antibody at 1 µg/ml.
  • IHC - SKI2W Antibody ASC11860
    Immunohistochemistry of SKI2W in human stomach tissue with SKI2W antibody at 5 µg/ml.
  • IF - SKI2W Antibody ASC11860
    Immunofluorescence of SKI2W in human stomach tissue with SKI2W antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15477
Other Accession NP_008860, 6499
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 113, 137 kDa

Observed: 135 kDa
Application Notes SKI2W antibody can be used for detection of SKI2W by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Additional Information
Gene ID 6499
Target/Specificity SKI2W antibody was raised against a 16 amino acid peptide near the amino terminus of human SKI2W.

The immunogen is located within amino acids 60 - 110 of SKI2W.
Reconstitution & Storage SKI2W antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSKI2W Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DDX13, SKI2W, SKIV2, W
Function Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Cellular Location Nucleus. Cytoplasm
Citations (0)

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SKI2W (SKIV2L, Helicase-like protein), a DEVH-box protein, is a component of the SKI complex which is involved in the regulation of translation and RNA turnover (1,2). SKI2W is a nucleolar and cytoplasmic protein that has a putative RNA helicase domain (2). The potential roles of Ski2W on the clearance of degraded nuclear and cytoplasmic RNA raised their possibilities as susceptibility genes of systemic lupus erythematosus (3,4).


Dangel AW, Shen L, Mendoza AR, et al. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family. Nucleic Acids Res. 1995; 23:2120-6.
Qu X, Yang Z, Zhang S, et al. The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes. Nucleic Acids Res. 1998; 26:4068-77.
Yang Z, Shen L, Dangel AW, et al. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. Genomics 1998; 53:338-47.
Yang Z, Qu X, and Yu CY. Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region. Front. Biosci. 2001; 6:D927-35.

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$ 330.00
Cat# ASC11860
Availability: 5-7days
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