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P2RX7 Antibody

  • WB - P2RX7 Antibody ASC11867
    Western blot analysis of P2RX7 in 3T3 cell lysate with P2RX7 antibody at (A) 1 and (B) 2 µg/ml.
  • ICC - P2RX7 Antibody ASC11867
    Immunocytochemistry of P2RX7 in 3T3 cells with P2RX7 antibody at 5 µg/mL.
  • IF - P2RX7 Antibody ASC11867
    Immunofluorescence of P2RX7 in 3T3 cells with P2RX7 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99572
Other Accession NP_002553, 300068987
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 34, 47, 65 kDa

Observed: 54 kDa
Application Notes P2RX7 antibody can be used for detection of P2RX7 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 5027
Target/Specificity P2RX7; P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.
Reconstitution & Storage P2RX7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsP2RX7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RX7
Function Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).
Cellular Location Cell membrane; Multi- pass membrane protein
Tissue Location Widely expressed with highest levels in brain and immune tissues.
Research Areas
Citations (0)

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The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).


Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 1996; 272:735-8.
North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.
Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.
Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.

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$ 330.00
Cat# ASC11867
Availability: 5-7days
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