|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_002236, 4504847|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 37 kDa |
Observed: 35 kDa
|Application Notes||KCNK1 antibody can be used for detection of KCNK1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||KCNK1; KCNK1 antibody is human, mouse and rat reactive. KCNK1 antibody is predicted to not cross-react with other KCNK proteins.|
|Reconstitution & Storage||KCNK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||KCNK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HOHO1, KCNO1, TWIK1|
|Function||Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney (PubMed:8605869).|
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Provided below are standard protocols that you may find useful for product applications.
The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2). KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1). Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3).
Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996; 15:1004-11.
Goldstein SA, Bockenhauer D, O’Kelly I, et al. Potassium leak channels and the KCNK family of two-P domain subunits. Nat. Rev. Neurosci. 2001; 2:175-84.
Zhou M, Xu G, Xie M, et al. TWIK-1 and TREK-2 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slides. J. Neurosci. 2009; 29:8551-64.
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