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SOX4 Antibody

  • WB - SOX4 Antibody ASC11902
    Western blot analysis of SOX4 in human testis tissue lysate with SOX4 antibody at 1 µg/ml.
  • IHC - SOX4 Antibody ASC11902
    Immunohistochemistry of SOX4 in rat testis tissue with SOX4 antibody at 5 µg/mL.
  • IF - SOX4 Antibody ASC11902
    Immunofluorescence of SOX4 in rat testis tissue with SOX4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06945
Other Accession NP_003098, 4507163
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 52 kDa

Observed: 520 kDa
Application Notes SOX4 antibody can be used for detection of SOX4 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 6659
Target/Specificity SOX4; SOX4 antibody is human, mouse and rat reactive.
Reconstitution & Storage SOX4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSOX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX4
Function Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:16631117}
Tissue Location Testis, brain, and heart.
Research Areas
Citations (0)

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SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate (1,2). It may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin) (3). SOX4 contains one HMG box DNA-binding domain and may function in the apoptosis pathway leading to cell death. It has also been suggested to play a role in tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development (4,5).


Wotton D, Lake RA, Farr CJ, et al. The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J. Biol. Chem. 1995; 270:7515-22.
Pan X, Li H, Zhang P, et al. Ubc9 interacts with SOX4 and represses its transcriptionalactivity. Biochem. Biophys. Res. Commun. 2006; 344:727-34.
Castillo SD, Matheu A, Mariani N, et al. Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer. Cancer Res. 2012; 72:176-86.
Zhang H, Alberich-Jorda M, Amabile G, et al. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell 2013; 24:575-88.

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$ 310.00
Cat# ASC11902
(40 western blots)
Availability: 5-7days
Bulk Size
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