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WSB1 Antibody

  • WB - WSB1 Antibody ASC11918
    Western blot analysis of WSB1 in human colon tissue lysate with WSB1 antibody at 1 µg/ml.
  • IHC - WSB1 Antibody ASC11918
    Immunohistochemistry of WSB1 in human colon tissue with WSB1 antibody at 5 µg/mL.
  • IF - WSB1 Antibody ASC11918
    Immunofluorescence of WSB1 in human colon tissue with WSB1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6I7
Other Accession NP_056441, 18677720
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 46 kDa

Observed: 46 kDa
Application Notes WSB1 antibody can be used for detection of WSB1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 26118
Target/Specificity WSB1; WSB1 antibody is human specific.
Reconstitution & Storage WSB1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsWSB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WSB1
Synonyms SWIP1
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
Citations (0)

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The WD repeat and SOCS box-containing 1 (WSB1, also known as SWIP1), is a member of the WD-protein subfamily (1). It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus and expressed as multiple alternatively spliced isoforms (1,2). WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2 (3). Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis (4,5).


Vasiliauskas D, Hancock S, Stern CD. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Mech. Dev. 1999; 82:79-94.
Nara H, Onoda T, Rahman M, et al. WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor. Cell Immunol. 2011; 269:54-9.
Lv W, Zhang Y, Wu Z, et al. Identification of WSB1 gene as an important regulator in the development of zebrafish embryo during midblastula transition. Acta Biochim. Biophys. Sin (Shanghai) 2008; 40:478-88.
Archange C, Nowak J, Garcia S, et al. The WSB1 gene is involved in pancreatic cancer progression. PLoS One 2008; 3:e2475.

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$ 310.00
Cat# ASC11918
(40 western blots)
Availability: 5-7days
Bulk Size
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