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WSB1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9Y6I7 |
| Other Accession | NP_056441, 18677720 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 46 kDa Observed: 46 kDa |
| Application Notes | WSB1 antibody can be used for detection of WSB1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 26118 |
|---|---|
| Target/Specificity | WSB1; WSB1 antibody is human specific. |
| Reconstitution & Storage | WSB1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | WSB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WSB1 |
|---|---|
| Synonyms | SWIP1 |
| Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The WD repeat and SOCS box-containing 1 (WSB1, also known as SWIP1), is a member of the WD-protein subfamily (1). It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus and expressed as multiple alternatively spliced isoforms (1,2). WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2 (3). Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis (4,5).
References
Vasiliauskas D, Hancock S, Stern CD. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Mech. Dev. 1999; 82:79-94.
Nara H, Onoda T, Rahman M, et al. WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor. Cell Immunol. 2011; 269:54-9.
Lv W, Zhang Y, Wu Z, et al. Identification of WSB1 gene as an important regulator in the development of zebrafish embryo during midblastula transition. Acta Biochim. Biophys. Sin (Shanghai) 2008; 40:478-88.
Archange C, Nowak J, Garcia S, et al. The WSB1 gene is involved in pancreatic cancer progression. PLoS One 2008; 3:e2475.
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