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MAGEA4 Antibody

  • WB - MAGEA4 Antibody ASC11929
    Western blot analysis of MAGEA4 in A431 cell lysate with MAGEA4 antibody at 1 µg/ml.
  • IF - MAGEA4 Antibody ASC11929
    Immunofluorescence of MAGEA4 in human breast cancer tissue with MAGEA4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43358
Other Accession NP_001011550, 58530871
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 35 kDa; Observed: 45 kDa
Application Notes MAGEA4 antibody can be used for detection of MAGEA4 by Western blot at 1 - 2 µg/ml. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 4103
Target/Specificity MAGEA4; MAGEA4 antibody is human specific. At least four isoforms of MAGEA4 are known to exist.
Reconstitution & Storage MAGEA4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsMAGEA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAGE4
Function Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta
Research Areas
Citations (0)

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MAGEA4 is a member of the melanoma-associated antigen family that consists of a number of antigens recognized by cytotoxic T lymphocytes (1). MAGEA4 may serve as a target for antitumoral vaccination and may play a role in embryonal development and tumor transformation or aspects of tumor progression. It is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma and have been implicated in some hereditary disorders, such as dyskeratosis congenital (2-4).


Bhan S, Negi SS, Shao C, et al. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin. Cancer Res. 2011; 17:4267-76.
Bhan S, Chuang A, Negi SS, et al. MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth arrest and apoptosis. Oncol. Rep. 2012; 28:1498-502.
Saito T, Wada H, Yamasaki M, et al. High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine. Vaccine, epub. 2014; S0264-410X(14)01217-1.
Zhang QM, He SJ, Shen N, et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. Int. J. Clin. Exp. Pathol. 2014; 7:3918-27.

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$ 310.00
Cat# ASC11929
(40 western blots)
Availability: 5-7days
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