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IZUMO1 Antibody

  • WB - IZUMO1 Antibody ASC11941
    Western blot analysis of IZUMO1 in human testis tissue lysate with IZUMO1 antibody at 1 µg/ml.
  • IHC - IZUMO1 Antibody ASC11941
    Immunohistochemistry of IZUMO1 in human testis tissue with IZUMO1 antibody at 2.5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IYV9
Other Accession NP_872381, 194097475
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 35, 39, 42 kDa; Observed: 52 kDa
Application Notes IZUMO1 antibody can be used for detection of IZUMO1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL.
Additional Information
Gene ID 284359
Target/Specificity IZUMO1; IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist; this antibody will detect the two longest isoforms.
Reconstitution & Storage IZUMO1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIZUMO1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9D9J7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D9J7}
Tissue Location Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction
Research Areas
Citations (0)

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IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).


Inoue N, Hamada D, Kamikubo H, et al. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development 2013; 140:3221-9.
Inoue N, Ikawa M, and Okabe M. The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian J. Androl. 2011; 13:81-7.
Xing WJ, Han BD, Wu Q, et al. Molecular cloning and characterization of Izumo1 gene from sheep and cashmere goat reveal alternative splicing. Mol. Biol. Rep. 2011; 38:1995-2006.
Inoue N, Ikawa M, Isotani A, et al. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 2005; 434:234-8.

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$ 330.00
Cat# ASC11941
Availability: 5-7days
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