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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DEPDC1B Antibody   

DEPDC1B Antibody

  • WB - DEPDC1B Antibody ASC11947
    Western blot analysis of DEPDC1B in K562 cell lysate with DEPDC1B antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WUY9
Other Accession NP_060839, 223633999
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 58 kDa

Observed: 57 kDa
Application Notes DEPDC1B antibody can be used for detection of DEPDC1B by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 55789
Target/Specificity DEPDC1B; DEPDC1B antibody is human specific. At least two isoforms are known to exist; this antibody will only detect the largest isoform. DEPDC1B antibody is predicted to not cross-react with DEPDC1A.
Reconstitution & Storage DEPDC1B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsDEPDC1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms XTP8
Research Areas
Citations (0)

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The DEP domain-containing 1B (DEPDC1B) protein was initially identified as a radiation response biomarker in human lymphoblastoid cell lines (1). Like the related protein DEPDC1A, expression of DEPDC1B correlates with a poor prognosis in cancer patients (2,3). Studies have shown that DEPDC1B levels are upregulated in non-small cell lung cancer (NSCLC) and have an inverse correlation with patient survival. Ectopic expression of DEPDC1B in NSCLC activated Wnt/B-catenin signaling and enhanced cell migration and invasion while silencing DEPDC1B expression suppressed these traits (2).


Niu N, Qin Y, Fridley BL, et al. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Res. 2010; 20:1482-92.
Yang Y, Liu L, Cai J, et al. DEPDC1B enhances migration and invasion of non-small cell lung cancer cells via activating Wnt/B-catenin signaling. Biochem. Biophys. Res. Commun. 2014; 450:899-905.
Kassambara A, Schoenhals M, Moreaux J, et al. Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. PLoS One 2013; 8:e62752.

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$ 310.00
Cat# ASC11947
(40 western blots)
Availability: 5-7days
Bulk Size
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