|Application ||WB, ICC, E|
|Other Accession||NP_060790, 21361732|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 24, 27, 36 kDa |
Observed: 28 kDa
|Application Notes||RNF121 antibody can be used for detection of RNF121 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunocytochemistry at 10 µg/ml.|
|Target/Specificity||RNF121; RNF121 antibody is human, mouse and rat reactive. Multiple isoforms of RNF121 are known to exist.|
|Reconstitution & Storage||RNF121 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||RNF121 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
RNF121 is an evolutionarily conserved E3 ligase ring finger protein that is expressed in the endoplasmic reticulum (1). It acts downstream of the unfolded protein response regulator protein kinase-like endoplasmic reticulum kinase (PERK). Overexpression of RNF121 during the early stages of gonad development led to aberrations in germline development and gonad migration, suggesting that it plays a role in endoplasmic reticulum-associated degradation machinery (1).
Darom A, Bening-Abu-Shach U, and Broday L. RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of B-integrin. Mol. Biol. Cell 2010; 21:1788-98.
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