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ORAI3 Antibody [1B4F1]

  • WB - ORAI3 Antibody [1B4F1]  ASC11998
    Western blot analysis of ORAI3 in rat lung tissue lysate with ORAI3 antibody at 2 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRQ5
Other Accession Q9BRQ5, 74732916
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 1B4F1
Calculated MW 31499 Da
Application Notes ORAI3 antibody can be used for detection of ORAI3 by Western blot at 2 µg/mL.
Additional Information
Gene ID 93129
Target/Specificity ORAI3;
Reconstitution & Storage ORAI3 monoclonal antibody can be stored at -20℃, stable for one year.
PrecautionsORAI3 Antibody [1B4F1] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORAI3
Synonyms TMEM142C
Function Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.
Cellular Location Membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.


Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.
Mercer JC, DeHaven WI, Smyth JT, et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J. Biol. Chem. 2006; 281:24979-90.

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$ 310.00
Cat# ASC11998
(40 western blots)
Availability: 5-7days
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