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ORAI1 Antibody [6D11A11]

  • WB - ORAI1 Antibody [6D11A11]  ASC12008
    Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - ORAI1 Antibody [6D11A11]  ASC12008
    Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 µg/mL.
  • IF - ORAI1 Antibody [6D11A11]  ASC12008
    Immunofluorescence of ORAI1 in Human Spleen tissue with ORAI1 antibody at 20 ug/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96D31
Other Accession Q96D31, 97180269
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 6D11A11
Calculated MW Predicted: 33 kDa

Observed: 50 kDa
Application Notes ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84876
Target/Specificity ORAI1; ORAI1 antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Reconstitution & Storage ORAI1 monoclonal antibody can be stored at -20℃, stable for one year.
PrecautionsORAI1 Antibody [6D11A11] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORAI1
Synonyms CRACM1, TMEM142A
Function Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
Cellular Location Cell membrane; Multi- pass membrane protein Note=Isoform beta is more mobile in the plasma membrane
Research Areas
Citations (0)

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ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.


Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.

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$ 310.00
Cat# ASC12008
(40 western blots)
Availability: 5-7days
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