TrpC4 Antibody
TRPC4 Antibody, Clone S77-15
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, IP, AM |
---|---|
Primary Accession | O35119 |
Other Accession | NP_001076584.1 |
Host | Mouse |
Isotype | IgG1 |
Reactivity | Human, Mouse, Rat |
Clonality | Monoclonal |
Description | Mouse Anti-Rat TrpC4 Monoclonal IgG1 |
Target/Specificity | Detects ~110kDa. |
Other Names | CCE1 Antibody, HTRP4 Antibody, STRPC4 Antibody, TRP4 Antibody, TRPC 4 Antibody, transient receptor potential 4 Antibody |
Clone Names | S77-15 |
Immunogen | Synthetic peptide amino acids 930-947 of rat TrpC4 |
Purification | Protein G Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 1 µg/ml of SMC-315 was sufficient for detection of TrpC4 in 10 µg of COS cell lysate transiently transfected with TrpC4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Cellular Localization | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name. They are expressed in smooth muscle and endothelial cells where they regulate membrane potential and calcium influx. TrpC4 is activated by G(q)/phospholipase C-coupled receptors, but the underlying mechanism remains elusive (1). Studies suggest TrpC4 contributes to axonal regeneration after nerve injury (2).
References
1. Otsuguro K., et al. (2008) J Biol Chem. 283(15): 10026-10036.
2. Wu D., Huang W., Richardson P.M., Pristly J.V., Liu M. (2008) J. Biol. Chem. 283(1): 416-426.
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