BK Beta 3a Antibody
BK Beta3a Antibody, Clone S40B-18
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, IP, AM |
---|---|
Primary Accession | Q9NPA1 |
Other Accession | NP_055222.3 |
Host | Mouse |
Isotype | IgG1 |
Reactivity | Human, Mouse, Rat |
Clonality | Monoclonal |
Description | Mouse Anti-Mouse BK Beta3a Monoclonal IgG1 |
Target/Specificity | Detects ~32 kDa. No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4. |
Other Names | HBETA3 Antibody, KCNMB2 Antibody, KCNMBL Antibody, BKBeta3 Antibody, KCNMB3 Antibody, Calcium-activated potassium channel subunit beta-3 Antibody, BK channel subunit beta-3 Antibody, BKbeta3 Antibody, Hbeta3 Antibody, Calcium-activated potassium channel Antibody, subfamily M subunit beta-3 Charybdotoxin receptor subunit beta-3 Antibody, K(VCA)beta-3 Antibody, Maxi K channel subunit beta-3 Antibody, Slo-beta-3 Antibody |
Clone Names | S40B-18 |
Immunogen | Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a |
Purification | Protein G Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 1 µg/ml of SMC-330 was sufficient for detection of BK Beta3a in 10 µg of COS cell (lysate) transiently transfected with BKbeta3a by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Cellular Localization | Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (1). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (2). This has major implications on other physiological processes in tissues other than the brain.
References
1. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1-13.
2. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481-1489.
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