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SHANK3 Antibody
SHANK3 Antibody, Clone S69-46
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP, AM |
|---|---|
| Primary Accession | Q9JLU4 |
| Other Accession | NP_067708.1 |
| Host | Mouse |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat SHANK3 Monoclonal IgG2b |
| Target/Specificity | Detects ~190kDa. No cross-reactivity against Shank1 or Shank2. |
| Other Names | AI841104 antibody, DEL22q13.3 antibody, KIAA1650 antibody, Proline rich synapse associated protein 2 antibody, Proline-rich synapse-associated protein 2 antibody, ProSAP2 antibody, PSAP2 antibody, SH3 and multiple ankyrin repeat domains 3 antibody, SH3 and multiple ankyrin repeat domains protein 3 antibody SH3/ankyrin domain gene 3 antibody, SHAN3_HUMAN antibody, Shank postsynaptic density protein antibody, Shank3 antibody, Shank3b antibody, SPANK 2 antibody, SPANK2 antibody |
| Clone Names | S69-46 |
| Immunogen | Synthetic peptide amino acids 840-857 of rat Shank3 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-336 was sufficient for detection of Shank3 in 10 µg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasm | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density |
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Provided below are standard protocols that you may find useful for product applications.
Background
Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
References
1. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856.
2. Schuetz G., et al. (2004) JCB. 167(5): 645-952.
3. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27.
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