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Clcn3 Antibody
ClCN3 Antibody, Clone S258-5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | P51792 |
| Other Accession | NP_445815.2 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat Clcn3 Monoclonal IgG1 |
| Target/Specificity | Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results). |
| Other Names | CIC3 Antibody, CLC3 Antibody, CLCN 3 Antibody, Chloride channel 3 Antibody, Chloride channel protein 3 Antibody, Chloride channel Antibody, voltage-sensitive 3 Antibody, Chloride transporter ClC 3 Antibody, DKFZp564I0463 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody, Chloride transporter ClC-3 Antibody, ClC-3 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody |
| Clone Names | S258-5 |
| Immunogen | Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3 |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-408 was sufficient for detection of Clcn3 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Membrane | Endosome | Endosome membrane | Cytoplasmic Vesicle | Secretory Vesicle Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
References
1. www.phosphosite.org/proteinAction.do?id=5088&showAllSites=true
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