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FGFA/FHFA (pan) Antibody
FGFA/FHFA (pan) Antibody, Clone S235-22
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q92913 |
| Other Accession | AAH34340 |
| Host | Mouse |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human FGFA/FHFA (pan) Monoclonal IgG2b |
| Target/Specificity | Detects ~30kDa. Does not cross-react with FGF13B/FHF2B. Cross reacts with FGF12A/FHF1A and FGF14A/FHF4A. |
| Other Names | Acidic fibroblast growth factor Antibody, AFGF Antibody, Beta endothelial cell growth factor Antibody, Fibroblast growth factor homologous factor 2A Antibody, Fibroblast growth factor 13A Antibody, FGF13A Antibody, Beta-endothelial cell growth factor Antibody, ECGF Antibody, ECGFA Antibody, ECGFB Antibody, Endothelial Cell Growth Factor alpha Antibody, Endothelial Cell Growth Factor alpha Antibody, Endothelial Cell Growth Factor beta Antibody, FGF 1 Antibody, FGF alpha Antibody, FGFA Antibody, Fibroblast Growth Factor 1 Acidic Antibody, Fibroblast growth factor 1 Antibody, GLIO703 Antibody, HBGF 1 Antibody, HBGF1 Antibody, Heparin binding growth factor 1 Antibody, Heparin binding growth factor 1 precursor Antibody, Heparin-binding growth factor 1 Antibody |
| Clone Names | S235-22 |
| Immunogen | Synthetic peptide amino acids 2-18 (AAAIASSLIRQKRQARE) of human FHF2A. 100% identical to rat, 94% identical to mouse. >80% identity with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-448 was sufficient for detection of FGFA/FHFA (pan) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Projection | Growth Cone | Dendrite | Nucleus | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
FGF13(Fibroblast growth factor 13), also called FHF2 is a protein that in humans is encoded by the FGF13 gene.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF13is a large gene, extending over approximately 200 kb in Xq26.3, and contains at least 7 exons. By cytogenetic, FISH, and database analysis, Gecz et al. (1999) localized the FGF13 gene within a 400-kb duplication interval on chromosome Xq26.3. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
References
1. Gecz, J., et al. (1999) Hum. Genet. 104: 56-63.
2. Smallwood, P. M., et al. (1996) Proc. Nat. Acad. Sci. 93: 9850-9857.
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