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INPP5F Antibody
INPP5F Antibody, Clone S166A-26
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q01968 |
| Other Accession | NP_000267.2 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human INPP5F Monoclonal IgG1 |
| Target/Specificity | Detects ~100kDa. Cross-reacts with INPP5b. |
| Other Names | EC 3.1.3.36 Antibody, Inositol polyphosphate 5 phosphatase OCRL 1 Antibody, Inositol polyphosphate 5 phosphatase OCRL1 Antibody, Inositol polyphosphate 5-phosphatase OCRL-1 Antibody, INPP5F Antibody, LOCR Antibody, Lowe oculocerebrorenal syndrome protein Antibody, NPHL2 Antibody, OCRL 1 Antibody, OCRL Antibody, OCRL_HUMAN Antibody, OCRL1 Antibody, Oculocerebrorenal syndrome of Lowe Antibody, Phosphatidylinositol polyphosphate 5 phosphatase Antibody |
| Clone Names | S166A-26 |
| Immunogen | Fusion protein amino acids 1-901 (full-length) of human INPP5F. Rat: 93% identity (845/904 amino acids identical). Mouse: 91% identity (824/901 amino acids identical) ~50% identity with INPP5b. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-464 was sufficient for detection of INPP5F in 20 µg of COS cells transiently transformed with GFP-tagged OCLR lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasmic Vesicle | Endosome | Endosome Membrane | Membrane | Golgi Apparatus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inositol polyphosphate 5-phosphatase OCRL-1 (INPP5F/OCRL) is also called Lowe oculocerebrorenal syndrome protein. INPP5F is a phosphotase that converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, as well as inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. ORCL is involved in primary cilia assembly and may also have a role in lysosomal membrane trafficking. ORCL is expressed in brain, skeletal muscle, heart, kidney, lung, placenta, fibroblasts, retina and the retinal pigment epithelium. INPP5F defects can cause Lowe oculocerebrorenal syndrome (OCRL) and Dent disease type 2 (DD2).
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