Trak2 Antibody
TRAK2 Antibody, Clone S390-43
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC |
---|---|
Primary Accession | O60296 |
Other Accession | NP_055864.2 |
Host | Mouse |
Isotype | IgG2A |
Reactivity | Human, Rat |
Clonality | Monoclonal |
Description | Mouse Anti-Human Trak2 Monoclonal IgG2A |
Target/Specificity | Detects ~100kDa. Does not cross-react with TRAK1. |
Other Names | Trafficking kinesin-binding protein 2 Antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein Antibody, GABA-A receptor-interacting factor 1 Antibody, O-GlcNAc transferase-interacting protein of 98 kDa Antibody, EMBL AAH60681.1 Antibody, Ensembl ENSMUSP00000027186 MGI 1918077 Antibody, Als2cr3 Antibody, Grif1 Antibody, Oip98 Antibody, KIAA0549 Antibody, TRAK2_Human Antibody |
Clone Names | S390-43 |
Immunogen | Fusion protein amino acids 757-914 (C-terminus) of human TRAK2 |
Purification | Protein G Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.1% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | A 1:100 dilution of SMC-483 was sufficient for detection of Trak2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Cellular Localization | Cytoplasm | Mitochondrion | Early Endosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRAK2, a member of the TRAK family of adaptor proteins, links mitochondria to microtubule based motors. Localized in dendrites, it is specifically required for dendritic development as it reacts with dynein and dynactin. TRAK2 interferes with kinesin-1 binding and axonal transport (1). It has been shown to interact with Kir2.1 and GABA-R Beta2 (2, 3).
References
1. van Spronsen M. et al. (2013) Neuron. 77(3): 48-502.
2. Grishin A., Li H., Levitan E.S., Zaks E. (2006) J Biol Chem. 281(4): 30104-30111.
3. Beck M., et al. (2002) J Biol Chem. 277(33): 30079-30090.
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