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ABCC2 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1005a | 50 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ABCC2 Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | Q92887 |
| Other Accession | NP_000383 |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 1C5 |
| Calculated MW | 174207 Da |
ABCC2 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 1244 | |
| Other Names ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | |
| Target/Specificity ABCC2 (NP_000383, 214 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCC2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCC2 Antibody (monoclonal) (M01) - Application data
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Detection limit for recombinant GST tagged ABCC2 is approximately 0.03ng/ml as a capture antibody.
ABCC2 Antibody (monoclonal) (M01) - Related products
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BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
REFERENCES
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia. Takahashi N, et al. J Hum Genet, 2010 Aug 19. PMID 20720558.Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Hu M, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20679960.Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. Woillard JB, et al. Br J Clin Pharmacol, 2010 Jun. PMID 20565459.Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. McLeod HL, et al. J Clin Oncol, 2010 Jul 10. PMID 20530282.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
