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ABCC2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ABCC2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92887 |
| Other Accession | NM_000392 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1C5 |
| Calculated MW | 174207 Da |
| Gene ID | 1244 |
|---|---|
| Other Names | Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Multidrug resistance-associated protein 2, ABCC2, CMOAT, CMOAT1, CMRP, MRP2 |
| Target/Specificity | ABCC2 (NP_000383, 214 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ABCC2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
References
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia. Takahashi N, et al. J Hum Genet, 2010 Aug 19. PMID 20720558.Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Hu M, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20679960.Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele. Woillard JB, et al. Br J Clin Pharmacol, 2010 Jun. PMID 20565459.Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. McLeod HL, et al. J Clin Oncol, 2010 Jul 10. PMID 20530282.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
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