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ACACA Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1018a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACACA Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | Q13085 |
| Other Accession | NP_942131 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 6H5 |
| Calculated MW | 265554 Da |
ACACA Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 31 | |
| Other Names ACAC, ACC, ACC1, ACCAacetyl-Coenzyme A carboxylase alpha | |
| Target/Specificity ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACACA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACACA Antibody (monoclonal) (M01) - Related products
ACACA Antibody (monoclonal) (M01) - Application data
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Detection limit for recombinant GST tagged ACACA is approximately 0.03ng/ml as a capture antibody.
ACACA Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua?o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Kim CW, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457939.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Zhao LF, et al. Endocr J, 2010. PMID 20139635.
