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ACADVL Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ACADVL.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P49748 |
| Other Accession | NM_000018 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 5D3 |
| Calculated MW | 70390 Da |
| Gene ID | 37 |
|---|---|
| Other Names | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial, VLCAD, ACADVL, VLCAD |
| Target/Specificity | ACADVL (NP_000009, 345 a.a. ~ 434 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ACADVL Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
1.ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies.Nouws J, Te Brinke H, Nijtmans LG, Houten SMHum Mol Genet. 2013 Nov 6.2.Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction.De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T.Am J Physiol Endocrinol Metab. 2012 May;302(9):E1123-41. Epub 2012 Feb 21.
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