|Application ||WB, IF, IP, E|
|Calculated MW||96147 Da|
|Other Names||Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76|
|Target/Specificity||AHR (NP_001612, 721 a.a. ~ 820 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||AHR Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
1.Gender matters: estrogen receptor alpha (ER?) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A).Kalthoff S, Winkler A, Freiberg N, Manns MP, Strassburg CPJ Hepatol. 2013 May 25. pii: S0168-8278(13)00360-7. doi: 10.1016/j.jhep.2013.05.028.2.Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells.Vlachos C, Schulte BM, Magiatis P, Adema GJ, Gaitanis G.Br J Dermatol. 2012 Apr 25. doi: 10.1111/j.1365-2133.2012.11014.x.3.Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.Schults MA, Timmermans L, Godschalk RW, Theys J, Wouters BG, van Schooten FJ, Chiu RK.J Biol Chem. 2010 May 7;285(19):14558-64. Epub 2010 Mar 12.
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