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AKR1C2 Antibody (monoclonal) (M03)

Mouse monoclonal antibody raised against a partial recombinant AKR1C2.

  • WB - AKR1C2 Antibody (monoclonal) (M03) AT1093a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - AKR1C2 Antibody (monoclonal) (M03) AT1093a
    Western Blot analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 monoclonal antibody (M03), clone 3C11.

    Lane 1: AKR1C2 transfected lysate(36.7 KDa).
    Lane 2: Non-transfected lysate.
  • E - AKR1C2 Antibody (monoclonal) (M03) AT1093a
    Detection limit for recombinant GST tagged AKR1C2 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P52895
Other Accession BC063574
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3C11
Calculated MW 36735 Da
Additional Information
Gene ID 1646
Other Names Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
Target/Specificity AKR1C2 (AAH63574, 224 a.a. ~ 323 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsAKR1C2 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.


1.Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.Hevir N, Vouk K, Sinkovec J, Ribic-Pucelj M, Lanisnik Rizner T.Chem Biol Interact. 2011 Jan 11. [Epub ahead of print]2.Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro.Takahashi RH, Bains OS, Pfeifer TA, Grigliatti TA, Reid RE, Riggs KW.Drug Metab Dispos. 2008 Jun;36(6):991-4. Epub 2008 Mar 5.

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$ 315.00
Cat# AT1093a
(40 western blots)
Availability: 7-10 days
Bulk Size
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