AKR1D1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant AKR1D1.
|Application ||WB, E|
|Calculated MW||37377 Da|
|Other Names||3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1|
|Target/Specificity||AKR1D1 (NP_005980, 227 a.a. ~ 326 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||AKR1D1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Steen NE, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 Aug 25. PMID 20800085.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Characterization of the human CREB3L2 gene promoter. Panagopoulos I, et al. Oncol Rep, 2009 Mar. PMID 19212619.SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency. Ueki I, et al. J Gastroenterol Hepatol, 2009 May. PMID 19175828.Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Faucher F, et al. Biochemistry, 2008 Dec 23. PMID 19075558.
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