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ASAH1 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1207a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ASAH1 Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | Q13510 |
| Other Accession | NP_808592 |
| Reactivity | Human |
| Isotype | IgG3 Kappa |
| Clone Names | 2C9 |
| Calculated MW | 44660 Da |
ASAH1 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 427 | |
| Other Names AC, ASAH, FLJ21558, FLJ22079, PHP, PHP32N-acylsphingosine amidohydrolase (acid ceramidase) 1 | |
| Target/Specificity ASAH1 (NP_808592, 25 a.a. ~ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ASAH1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ASAH1 Antibody (monoclonal) (M01) - Application data
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Immunoperoxidase of monoclonal antibody to ASAH1 ( Cat # AT1207a ) on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml]
ASAH1 Antibody (monoclonal) (M01) - Related products
RI10427: ASAH1 predesign siRNA
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BACKGROUND
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer. Ruckh?berle E, et al. Climacteric, 2009 Dec. PMID 19905902.The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Lucki N, et al. Biochim Biophys Acta, 2009 Aug. PMID 19298866.
