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>   home   >   Products   >   Primary Antibodies   >   ATRX Antibody (monoclonal) (M01)   

ATRX Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant ATRX.

  • WB - ATRX Antibody (monoclonal) (M01) AT1246a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • E - ATRX Antibody (monoclonal) (M01) AT1246a
    Detection limit for recombinant GST tagged ATRX is approximately 0.1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46100
Other Accession NM_000489
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 3C9
Calculated MW 282586 Da
Additional Information
Gene ID 546
Other Names Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX, RAD54L, XH2
Target/Specificity ATRX (NP_000480, 2311 a.a. ~ 2410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsATRX Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.


ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Kernohan KD, et al. Dev Cell, 2010 Feb 16. PMID 20159591.Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. Lukashchuk V, et al. J Virol, 2010 Apr. PMID 20147399.ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Wong LH, et al. Genome Res, 2010 Mar. PMID 20110566.Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants. Breuer T, et al. Acta Anaesthesiol Scand, 2010 Apr. PMID 19919584.Partial ATRX gene duplication causes ATR-X syndrome. Cohn DM, et al. Am J Med Genet A, 2009 Oct. PMID 19764021.

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$ 315.00
Cat# AT1246a
(40 western blots)
Availability: 7-10 days
Bulk Size
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