B4GALNT1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant B4GALNT1.
|Application ||WB, E|
|Calculated MW||58882 Da|
|Other Names||Beta-1, 4 N-acetylgalactosaminyltransferase 1, (N-acetylneuraminyl)-galactosylglucosylceramide, GM2/GD2 synthase, GalNAc-T, B4GALNT1, GALGT, SIAT2|
|Target/Specificity||B4GALNT1 (NP_001469, 30 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||B4GALNT1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.
Analysis of GD2/GM2 synthase mRNA as a biomarker for small cell lung cancer. Chen LC, et al. Lung Cancer, 2010 Feb. PMID 19457569.Glycosyltransferase B4GALNT1 and type 1 diabetes in Croatian population: clinical investigation. Boraska V, et al. Clin Biochem, 2009 Jun. PMID 19318031.Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR. Gornati R, et al. Mol Cell Biochem, 2007 Apr. PMID 17119850.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains. Li J, et al. J Biol Chem, 2000 Dec 29. PMID 11018043.
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