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BACH1 Antibody (monoclonal) (M02)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1258a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
BACH1 Antibody (monoclonal) (M02) - Product info | |
| Application | WB
|
| Primary Accession | O14867 |
| Other Accession | NP_996749 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 1B8 |
| Calculated MW | 81958 Da |
BACH1 Antibody (monoclonal) (M02) - Additional info | |
| Gene ID 571 | |
| Other Names BTB and CNC homology 1, basic leucine zipper transcription factor 1 | |
| Target/Specificity BACH1 (NP_996749, 396 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BACH1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BACH1 Antibody (monoclonal) (M02) - Related products
BACH1 Antibody (monoclonal) (M02) - Application data
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BACH1 monoclonal antibody (M02), clone 1B8 Western Blot analysis of BACH1 expression in NIH/3T3 ( Cat # L018V1 ).
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Detection limit for recombinant GST tagged BACH1 is approximately 0.03ng/ml as a capture antibody.
BACH1 Antibody (monoclonal) (M02) - Research Areas
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BACKGROUND
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
REFERENCES
Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Miyazaki T, et al. Cancer Sci, 2010 Jun. PMID 20345481.BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Gong Z, et al. Mol Cell, 2010 Feb 12. PMID 20159562.MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. Hou W, et al. Hepatology, 2010 May. PMID 20127796.A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes. Zhong JL, et al. Free Radic Biol Med, 2010 Jan 15. PMID 19874887.Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. Goven D, et al. FEBS Lett, 2009 Nov 3. PMID 19822148.
