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BBOX1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant BBOX1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | O75936 |
| Other Accession | NM_003986 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6H3 |
| Calculated MW | 44715 Da |
| Gene ID | 8424 |
|---|---|
| Other Names | Gamma-butyrobetaine dioxygenase, Gamma-butyrobetaine hydroxylase, Gamma-BBH, Gamma-butyrobetaine, 2-oxoglutarate dioxygenase, BBOX1, BBH, BBOX |
| Target/Specificity | BBOX1 (NP_003977, 278 a.a. ~ 387 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | BBOX1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation.
References
Crystal structure of human gamma-butyrobetaine hydroxylase. Tars K, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20599753.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Genomic structure, alternative maturation and tissue expression of the human BBOX1 gene. Rigault C, et al. Biochim Biophys Acta, 2006 Dec. PMID 17110165.
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