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>   home   >   Products   >   Primary Antibodies   >   BCAR3 Antibody (monoclonal) (M01)   

BCAR3 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant BCAR3.

  • WB - BCAR3 Antibody (monoclonal) (M01) AT1278a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.51 KDa) .
  • E - BCAR3 Antibody (monoclonal) (M01) AT1278a
    Detection limit for recombinant GST tagged BCAR3 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75815
Other Accession BC039895
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3G4
Calculated MW 92566 Da
Additional Information
Gene ID 8412
Other Names Breast cancer anti-estrogen resistance protein 3, Novel SH2-containing protein 2, SH2 domain-containing protein 3B, BCAR3, NSP2, SH2D3B
Target/Specificity BCAR3 (AAH39895, 266 a.a. ~ 373 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsBCAR3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. Schuh NR, et al. J Biol Chem, 2010 Jan 22. PMID 19940159.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Makkinje A, et al. Cell Signal, 2009 Sep. PMID 19454314.BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. Oh MJ, et al. Biochem Biophys Res Commun, 2008 Oct 24. PMID 18722344.

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$ 315.00
Cat# AT1278a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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