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BGN Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a full length recombinant BGN.

  • WB - BGN Antibody (monoclonal) (M02) AT1296a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (66.22 KDa) .
  • WB - BGN Antibody (monoclonal) (M02) AT1296a
    Western Blot analysis of BGN expression in transfected 293T cell line by BGN monoclonal antibody (M02), clone 2E6-D1.

    Lane 1: BGN transfected lysate(41.7 KDa).
    Lane 2: Non-transfected lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21810
Other Accession BC002416
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a kappa
Clone Names 2E6-D1
Calculated MW 41654 Da
Additional Information
Gene ID 633
Other Names Biglycan, Bone/cartilage proteoglycan I, PG-S1, BGN, SLRR1A
Target/Specificity BGN (AAH02416.1, 1 a.a. ~ 368 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsBGN Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.


Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation. Yang SN, et al. Arch Physiol Biochem, 2009 Jul. PMID 19580379.Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness. Sardo MA, et al. Clin Chim Acta, 2009 Aug. PMID 19523462.ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan. Hiukka A, et al. Diabetes, 2009 Sep. PMID 19502413.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance. Kilts T, et al. Scand J Med Sci Sports, 2009 Aug. PMID 19422643.

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$ 315.00
Cat# AT1296a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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