BIN1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant BIN1.
|Calculated MW||64699 Da|
|Other Names||Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1, AMPHL|
|Target/Specificity||BIN1 (NP_004296, 355 a.a. ~ 454 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||BIN1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Genetic variation and neuroimaging measures in Alzheimer disease. Biffi A, et al. Arch Neurol, 2010 Jun. PMID 20558387.Genome-wide analysis of genetic loci associated with Alzheimer disease. Seshadri S, et al. JAMA, 2010 May 12. PMID 20460622.Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315.BIN1 localizes the L-type calcium channel to cardiac T-tubules. Hong TT, et al. PLoS Biol, 2010 Feb 16. PMID 20169111.Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation. Claeys KG, et al. Neurology, 2010 Feb 9. PMID 20142620.
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